Ageing Vulnerability
-15%
portes grátis
Ageing Vulnerability
Causes and Interventions
Bock, Gregory R.; Goode, Jamie A.
John Wiley & Sons Inc
02/2001
300
Dura
Inglês
9780471494386
15 a 20 dias
580
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Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation,
London, 29 February^3 March 2000
Editors: Gregory Bock (Organizer) and Jamie A. Goode
This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project 'A Research Agenda on Ageing for the 21st Century'
Thomas B. L. Kirkwood Introduction 1
Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4
Discussion 9
Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11
Discussion 20
Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26
Discussion 38
General discussion I The role of glial cells in the ageing brain 44
R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O'Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49
Discussion 60
C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66
Discussion 79
Amiela Globerson Haematopoietic stem cell ageing 85
Discussion 96
General discussion II 101
James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105
Discussion 110
Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116
Discussion 125
Rita B. E!ros Ageing and the immune system 130
Discussion 139
General discussion III 146
Lis Mosekilde Mechanisms of age-related bone loss 150
Discussion 166
Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172
Discussion 196
Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202
Discussion 212
General discussion IV 217
Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221
Discussion 230
D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234
Discussion 243
Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247
Discussion 263
Final discussion 267
Index of contributors 273
Subject index 275
London, 29 February^3 March 2000
Editors: Gregory Bock (Organizer) and Jamie A. Goode
This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project 'A Research Agenda on Ageing for the 21st Century'
Thomas B. L. Kirkwood Introduction 1
Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4
Discussion 9
Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11
Discussion 20
Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26
Discussion 38
General discussion I The role of glial cells in the ageing brain 44
R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O'Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49
Discussion 60
C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66
Discussion 79
Amiela Globerson Haematopoietic stem cell ageing 85
Discussion 96
General discussion II 101
James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105
Discussion 110
Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116
Discussion 125
Rita B. E!ros Ageing and the immune system 130
Discussion 139
General discussion III 146
Lis Mosekilde Mechanisms of age-related bone loss 150
Discussion 166
Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172
Discussion 196
Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202
Discussion 212
General discussion IV 217
Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221
Discussion 230
D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234
Discussion 243
Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247
Discussion 263
Final discussion 267
Index of contributors 273
Subject index 275
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Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation,
London, 29 February^3 March 2000
Editors: Gregory Bock (Organizer) and Jamie A. Goode
This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project 'A Research Agenda on Ageing for the 21st Century'
Thomas B. L. Kirkwood Introduction 1
Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4
Discussion 9
Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11
Discussion 20
Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26
Discussion 38
General discussion I The role of glial cells in the ageing brain 44
R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O'Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49
Discussion 60
C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66
Discussion 79
Amiela Globerson Haematopoietic stem cell ageing 85
Discussion 96
General discussion II 101
James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105
Discussion 110
Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116
Discussion 125
Rita B. E!ros Ageing and the immune system 130
Discussion 139
General discussion III 146
Lis Mosekilde Mechanisms of age-related bone loss 150
Discussion 166
Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172
Discussion 196
Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202
Discussion 212
General discussion IV 217
Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221
Discussion 230
D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234
Discussion 243
Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247
Discussion 263
Final discussion 267
Index of contributors 273
Subject index 275
London, 29 February^3 March 2000
Editors: Gregory Bock (Organizer) and Jamie A. Goode
This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project 'A Research Agenda on Ageing for the 21st Century'
Thomas B. L. Kirkwood Introduction 1
Gary R. Andrews The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century 4
Discussion 9
Julie K. Andersen Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 11
Discussion 20
Ashley I. Bush and Lee E. Goldstein Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts 26
Discussion 38
General discussion I The role of glial cells in the ageing brain 44
R.N. Kalaria, C.G. Ballard, P.G. Ince, R.A. Kenny, I.G. McKeith, C.M. Morris, J.T. O'Brien, E. K. Perry, R.H. Perry and J. A. Edwardson Multiple substrates of late-onset dementia: implications for brain protection 49
Discussion 60
C. S. Potten, K. Martin and T. B. L. Kirkwood Ageing of murine small intestinal stem cells 66
Discussion 79
Amiela Globerson Haematopoietic stem cell ageing 85
Discussion 96
General discussion II 101
James K. Leung and Olivia M. Pereira-Smith Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing 105
Discussion 110
Jerry W. Shay and Woodring E.Wright Ageing and cancer: the telomere and telomerase connection 116
Discussion 125
Rita B. E!ros Ageing and the immune system 130
Discussion 139
General discussion III 146
Lis Mosekilde Mechanisms of age-related bone loss 150
Discussion 166
Edward G. Lakatta, Steven J. Sollott and Salvatore Pepe The old heart: operating on the edge 172
Discussion 196
Anthony Cerami and Peter Ulrich Pharmaceutical intervention of advanced glycation end products 202
Discussion 212
General discussion IV 217
Holly Van Remmen, Zhongmao Guo and Arlan Richardson The anti-ageing action of dietary restriction 221
Discussion 230
D. A. Cottrell, E. L. Blakely, M. A. Johnson, G.M. Borthwick, P. I. Ince and D. M. Turnbull Mitochondrial DNA mutations in disease and ageing 234
Discussion 243
Douglas C. Wallace A mitochondrial paradigm for degenerative diseases and ageing 247
Discussion 263
Final discussion 267
Index of contributors 273
Subject index 275
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
